Gourav Bharat Deshmane
Bharati Vidyapeeth University, India
Title: Study efficacy of Krishnavajrabhraka Bhasma in chronic asthma
Biography
Biography: Gourav Bharat Deshmane
Abstract
Introduction: Chronic asthma is chronic airway inflammation leading to hyper-responsiveness of tracheo-bronchial tree. Steroids, being anti-inflammatory, are the mainstay of the treatment but have multiple adverse reactions. Krishnavajrabhraka Bhasma (KVB) is the herbo-mineral formulation claimed to be effective in chronic asthma. Present study was carried out to assess anti-asthmatic activity of KVB. Aim: To evaluate the efficacy of Krishnavajrabhraka Bhasma (KVB) in animal models of chronic bronchial asthma. Methods: After acute, sub-acute and chronic toxicity studies, KVB was evaluated for efficacy in animal models of chronic asthma. In all the experiments, 30 animals were divided into 5 groups and accordingly treatment was given: Vehicle (water), vehicle (honey water), Low dose KVB, High dose KVB and Prednisolone. Expt.I (Bronchial hyper-reactivity): On day 1, G. pigs were sensitized with egg albumin (EA). From 22nd day, they were treated for 21 days. At the end, pre-convulsive time was noted after EA challenge. Expt.II (Bronchial remodeling): After repeated challenges with EA aerosol for 4 weeks, rats were treated for 15 days. After rechallenge, broncho-alveolar lavage fluid was collected for analysis. Animals were sacrificed & lungs removed for histopathology. Results: Expt.I: KVB in high dose showed significant (p<0.01) increase in pre-convulsive time when compared to control groups. Expt.II: KVB significantly reduced (p<0.01) total eosinophil count in lavage fluid & also bronchial smooth muscle thickness compared to control. Results in both these experiments were comparable to Prednisolone. Conclusion: KVB was found to be effective in chronic asthma.